They are substances that temporarily change the way x-rays or other imaging tools interact with the body. Contrast materials, also known as contrast agents or contrast media, are used to improve the diagnostic value of those imaging exams.Ĭontrast materials are not dyes that permanently discolor internal organs. Imaging exams such as x-rays, ultrasound, computed tomography (CT), magnetic resonance (MRI), and fluoroscopy are selected based on their ability to show specific information about the structures within the body. When a physician needs to understand what is happening inside our bodies, they often request that a patient undergo an imaging exam. This content was issued through the press release distribution service at are contrast materials and how do they work? Image 1: Reveal's New Manganese-Based MRI Contrast Agent Advances Safer Patient Care The content is solely the responsibility of the authors and may not represent the official views of the NIH. Learn more at This trial (NCT05413668) is supported by SBIR grant R44CA268392 from the National Cancer Institute (NCI) of the National Institutes of Health (NIH). Reveal's pipeline focuses on molecular imaging of fibrogenesis. Reveal Pharmaceuticals' mission is to improve patient care with transformative advances in medical insight: its gadolinium-free contrast agent has won support from three institutes of the NIH and from Massachusetts Life Sciences Center, MassChallenge, and MassVentures. "Physicians and patients increasingly avoid CE-MRI due to concerns about gadolinium. Gadolinium-free RVP‑001 allays these concerns and provides promise for patients to receive the imaging studies they need." "RVP‑001 promises to directly replace gadolinium-based contrast agents and use established radiology protocols developed over decades of CE-MRI," said Srinivasan Mukundan, Reveal's medical director and former chief of MRI and Neuroradiology at Brigham Health. The National Cancer Institute, part of the National Institutes of Health, is funding the US-based clinical trial. RVP‑001 was invented by Peter Caravan and Eric Gale at Harvard Medical School / Massachusetts General Hospital. Instead of gadolinium, RVP‑001 uses manganese, which is essential for life and naturally found in the body. Gadolinium used in CE‑MRI scans not only impacts patients with buildup of the heavy metal in the brain and body, but also impacts the environment by driving rising levels of gadolinium in the earth's surface waters. Each year over 40 million contrast-enhanced (CE) MRI scans are used to diagnose and manage many serious health conditions. The Phase 1 study is designed to determine the safety, tolerability, and pharmacokinetics of RVP‑001. "Despite years of effort, this is the first time a general-purpose gadolinium-free contrast agent has been innovated and clinically tested." "The start of clinical trials is a tremendous milestone in advancing patient care," said Vera Hoffman, CEO of Reveal. Reveal Pharmaceuticals has dosed the first subjects in the Phase 1 clinical trial of RVP‑001. Now, a revolutionary gadolinium-free contrast agent, RVP‑001, designed to provide safer contrast-enhanced MRIs for patients and to directly replace current MRI contrast agents, is being tested for the first time in a clinical trial. CAMBRIDGE, Mass., J(GLOBE NEWSWIRE) - Contrast agents used in MRI scans to improve the clarity of imaging for diagnostic accuracy, accumulate in the brain and body of every patient, and carry an FDA "black box" warning about gadolinium, a heavy metal they use to generate contrast.
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